Oxidative stress and neuroinflammation in the story of Parkinson's disease: Could targeting these pathways write a good ending?. Issue 1 (4th August 2018)

• Record Type: Journal Article
• Authors: Hassanzadeh, Kambiz; Rahimmi, Arman
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 1(2019:Jan.)
• Page Start: 23
• Page End: 32
• Publication Date: 2018-08-04
• Subjects: antioxidants -- neuroinflammation -- oxidative stress -- Parkinson's disease; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.26865
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : Although, current medications for Parkinson's disease can control and relief symptoms of the disease efficiently, they are unable to either prevent progression of the disease or maintain their controlling ability as a long‐term medication. To find suitable adjuvant and/or alternative treatments, researchers have investigated antioxidative and anti‐inflammatory approaches, since emerging evidence consider oxidative stress and neuroinflammation as leading causes of the development of Parkinson's disease. Here, how oxidative stress and neuroinflammation take part in Parkinson's disease pathogenesis was discussed based on featured studies in this context. Then, preclinical and clinical trial studies, which evaluated antioxidative and anti‐inflammatory compounds' ability to treat Parkinson's disease, were reviewed. Abstract : The review looks into Parkinson's disease pathogenesis and its association with oxidative stress and neuroinflammation. It also highlights the studies on antioxidative and anti‐inflammatory approaches as future therapies for PD. The article mentions progresses, obstacles, and perspectives of such approaches.