Pathophysiological significance of calcium signaling at Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs). Issue 17 (October 2020)

• Record Type: Journal Article
• Authors: Sharma, Nutan; Arora, Samriddhi; Saurav, Suman; Motiani, Rajender K
• Is Part Of: Current opinion in physiology. Issue 17(2020)
• Page Start: 234
• Page End: 242
• Publication Date: 2020-10
• Subjects: Physiology -- Periodicals; Physiological Phenomena; Periodical; Fulltext; Internet Resources; Periodicals; 571
• DOI: 10.1016/j.cophys.2020.08.012
• Languages: English
• ISSNs: 2468-8673

Abstract

Abstract : Efficient inter-organelle communication is critical for maintaining cellular physiology and driving cell functions. Endoplasmic reticulum (ER) is involved in several such inter-organellar crosstalks with mitochondria, lysosomes, Golgi complex, endosomes and peroxisomes. The functional tethering of ER and mitochondria at Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) provides a signaling hotspot for transfer of lipid and calcium (Ca 2+ ) across these organelles. In last two decades, vital role for Ca 2+ signaling at MAMs has been demonstrated in driving cell physiology. Recent studies have demonstrated that perturbations in Ca 2+ signaling at MAMs lead to pathophysiological conditions such as cardiovascular diseases, metabolic disorders, cancers and neurodegenerative conditions. In this review, we would briefly discuss the key MAMs constituents that regulate Ca 2+ signaling at these sites. Further, we would revisit the literature-demonstrating role of Ca 2+ dynamics at MAMs in human pathophysiology and would highlight major unanswered questions.