Rapid infusion of fish oil‐based lipid emulsions: Is there a risk of fat overload syndrome? A case report of rapid administration. (18th March 2022)

• Record Type: Journal Article
• Authors: Burdine, Jordan; Franco‐Fuenmayor, Maria E.; Huff, Monica L.; Shattuck, Karen E.
• Is Part Of: Journal of clinical pharmacy and therapeutics. Volume 47:Number 7(2022)
• Page Start: 1088
• Page End: 1090
• Publication Date: 2022-03-18
• Subjects: fish‐oil lipid emulsion -- neonates -- Intravenous Infusions; Clinical pharmacology -- Periodicals; Chemotherapy -- Periodicals; 615
• DOI: 10.1111/jcpt.13639
• Languages: English
• ISSNs: 0269-4727

Abstract

Abstract: What is known and objectives: Errors involving the delivery of IVFE containing soybean oil have known significant complications, including fat overload syndrome. However, little is known regarding the risks of fat overload syndrome with other types of lipid emulsions. Case summary: We describe a medication administration error that resulted in rapid fish oil‐base lipid emulsion (Omegaven) infusion in a five‐month‐old infant with parenteral nutrition associated liver disease (PNALD). The medication administration error resulted in bolus infusion of Omegaven over 12 min (5 g/kg/h) instead of 12 h (0.083 g/kg/h). What is new and conclusion: No adverse reactions were notes because of the rapid infusion, supporting conclusion that rapid infusion of fish oil will not result in fat overload syndrome. Abstract : Errors involving the delivery of IVFE containing soybean oil have known significant complications, including fat overload syndrome; while little is known regarding the risks with other types of lipid emulsions. We describe a case of rapid fish oil‐base lipid emulsion (Omegaven) infusion in a five‐month‐old infant in which no adverse reactions were noted.