Management and outcomes of gastrointestinal congenital anomalies in low, middle and high income countries: protocol for a multicentre, international, prospective cohort study. Issue 8 (3rd September 2019)

• Record Type: Journal Article
• Authors: Wright, Naomi Jane
• Other Names: author non-byline.; Wright Naomi author non-byline.; Leather Andrew author non-byline.; Sevdalis Nick author non-byline.; Ade-Ajayi Niyi author non-byline.; Ademuyiwa Adesoji author non-byline.; Ameh Emmanuel author non-byline.; Davies Justine author non-byline.; Lakhoo Kokila author non-byline.; Poenaru Dan author non-byline.; Smith Emily author non-byline.; Ubhi Harmony author non-byline.; Parker Samuel author non-byline.; Philipo Godfrey Sama author non-byline.; Abukhalaf Sadi author non-byline.; Adofo-Ansong Nana author non-byline.; Akhbari Melika author non-byline.; Alhamid Ahmad author non-byline.; Alser Osaid H. author non-byline.; Aydin Emrah author non-byline.; Benaskeur Yousra-Imane author non-byline.; Elghazaly Shrouk M. author non-byline.; Elrais Safa Abdal author non-byline.; Hashim Sophia author non-byline.; Herrera Laura author non-byline.; Hyman Gabriella author non-byline.; Kwasau Henang author non-byline.; Liu Yang author non-byline.; Martinez-Leo Bruno author non-byline.; Naranjo Kelly author non-byline.; Nour Ibrahim author non-byline.; Riboni Cristiana author non-byline.; Saleh Mahmoud author non-byline.; Salem Hosni Khairy author non-byline.; Shinondo Patricia author non-byline.; Sim Marcus author non-byline.; Thompson Hannah author non-byline.; Vaitkiene Agota author non-byline.; Vervoort Dominique author non-byline.; Williams Isabelle author non-byline.; Yunus Aayenah author non-byline.; Chaudhary Muhammad Amjad author non-byline.; Khattak Muhammad Adnan Khan author non-byline.; Bin Amjad Muhammad author non-byline.; Dominguez Anaya Marlene author non-byline.; Hasan Samiul author non-byline.; Karim Sabbir author non-byline.; Mitul Ashrarur Rahman author non-byline.; Bragagnini Paolo author non-byline.; Rite Segundo author non-byline.; Arbab Hana author non-byline.; Samad Lubna author non-byline.; Soomro Aqil author non-byline.; Maistry Niveshni author non-byline.; Al-Taher Raed Nael author non-byline.; Nour Ibrahim Rabi author non-byline.; Sarhan Osama Abdul Kareen author non-byline.; Arshad Muhammad author non-byline.; Qureshi Taimur author non-byline.; Yousaf Hina author non-byline.; Choo Candy S.C. author non-byline.; Dimatatac Doris Mae author non-byline.; Nah Shireen Anne author non-byline.; Ismavel Vijay Anand author non-byline.; Miriam Ann author non-byline.; T Shajin author non-byline.; Ivanov Monica author non-byline.; Serban Andreea author non-byline.; Blazquez-Gomez Eva author non-byline.; Garcia-Aparicio Luis author non-byline.; Iriondo Marti author non-byline.; Prat Jordi author non-byline.; Tarrado Xavier author non-byline.; Hagander Lars author non-byline.; Svensson Emma author non-byline.; Abdul-Mumin Alhassan author non-byline.; Bagbio Dominic author non-byline.; Owusu Sheila author non-byline.; Tabiri Stephen author non-byline.; Aziz Dayang Anita Abdul author non-byline.;
• Is Part Of: BMJ open. Volume 9:Issue 8(2019)
• Publication Date: 2019-09-03
• Subjects: paediatric surgery -- paediatric anaesthesia -- paediatric intensive and critical care -- neonatology -- paediatrics -- neonatal intensive and critical care; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2019-030452
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Congenital anomalies are the fifth leading cause of death in children <5 years of age globally, contributing an estimated half a million deaths per year. Very limited literature exists from low and middle income countries (LMICs) where most of these deaths occur. The Global PaedSurg Research Collaboration aims to undertake the first multicentre, international, prospective cohort study of a selection of common congenital anomalies comparing management and outcomes between low, middle and high income countries (HICs) globally. Methods and analysis: The Global PaedSurg Research Collaboration consists of surgeons, paediatricians, anaesthetists and allied healthcare professionals involved in the surgical care of children globally. Collaborators will prospectively collect observational data on consecutive patients presenting for the first time, with one of seven common congenital anomalies (oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation and Hirschsprung's disease). Patient recruitment will be for a minimum of 1 month from October 2018 to April 2019 with a 30-day post-primary intervention follow-up period. Anonymous data will be collected on patient demographics, clinical status, interventions and outcomes using REDCap. Collaborators will complete a survey regarding the resources and facilities for neonatal and paediatric surgery at their centre. The primary outcome is all-cause in-hospital mortality. Secondary outcomes include the occurrence of post-operative complications. Chi-squared analysis will be used to compare mortality between LMICs and HICs. Multilevel, multivariate logistic regression analysis will be undertaken to identify patient-level and hospital-level factors affecting outcomes with adjustment for confounding factors. Ethics and dissemination: At the host centre, this study is classified as an audit not requiring ethical approval. All participating collaborators have gained local approval in accordance with their institutional ethical regulations. Collaborators will be encouraged to present the results locally, nationally and internationally. The results will be submitted for open access publication in a peer reviewed journal. Trial registration number: NCT03666767