Serum Levels of Biochemical Markers of Traumatic Brain Injury. (19th January 2012)

• Record Type: Journal Article
• Authors: Borg, Keith; Bonomo, Jordan; Jauch, Edward C.; Kupchak, Peter; Stanton, Eric B.; Sawadsky, Bruce
• Other Names: Attri A. K. Academic Editor.; Eisenburger P. Academic Editor.; Kloeck W. Academic Editor.
• Is Part Of: ISRN emergency medicine. Volume 2012(2012)
• Publication Date: 2012-01-19
• Subjects: Emergency medical services -- Periodicals; Emergency medicine -- Periodicals; Emergency Medicine; Emergency medical services; Emergency medicine; Electronic journals; Periodical; Periodicals; 616.025
• DOI: 10.5402/2012/417313
• Languages: English
• ISSNs: 2090-5629

Abstract

Abstract : Background . A biomarker would be valuable in the diagnosis, risk stratification and prognosis of patients with traumatic brain injury (TBI). Methods . We measured serum levels of S-100β, neuron specific enolase (NSE) and myelin basic protein (MBP) in 50 TBI subjects, and 50 age and gender matched controls. Patients were recruited within 6 hours of the initial injury, they had an initial Glasgow Coma Scale (GCS) score of 14 or less, or a GCS score of 15 with witnessed loss of consciousness (LOC) or amnesia. Results . S-100β, NSE and MBP levels were significantly higher in TBI subjects than in control subjects (P < 0.001 for S-100β and NSE; P = 0.009 for MBP). Initial S-100β levels were significantly higher in TBI subjects who had not retuned to normal activities 2 weeks following their injury than in TBI subjects who had retuned to normal activities (P = 0.022 ). MBP levels were higher in TBI subjects with positive findings on the baseline CT scan than in CT-negative subjects (P = 0.007 ). Conclusions . S-100β, NSE and MBP may be present in the sera of TBI subjects in elevated quantities relative to controls. S-100β may aid in predicting short-term outcome in TBI subjects.