892 Quality of Life After Pancreaticoduodenectomy. (19th August 2022)

• Record Type: Journal Article
• Authors: Russell, J; Guildford, N; Karavias, D; Hamady, Z
• Is Part Of: British journal of surgery. Volume 109(2022)Supplement 6
• Publication Date: 2022-08-19
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1093/bjs/znac269.383
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract: Aim: Pancreaticoduodenectomy (PD) can severely impair quality of life (QOL) and alter normal activities. The European Organization for Research and Treatment of Cancer QOL questionnaire (EORTC QLQ-C30) is an integrated system for assessing QOL in cancer patients. The aim was to evaluate the QOL outcomes for patients who undergo PD over a six-month period peri-operatively. Method: EORTC QLQ-C30 (v.3) and pancreas-specific (PAN26) questionnaires were offered to patients who underwent PD between July 2018 and March 2019. Patients were invited to complete the questionnaire three times (1–2 weeks pre-operatively, 2–6 weeks post discharge, and 6–8 months post-operatively. Patients were excluded if they did not complete >50% of the questions for at least two consecutive questionnaires. Scores were calculated in accordance with the EORTC QLQ-C30 (version 3) core questionnaire manual. Data was analysed using Cohen's effect size and one way analysis of variance (ANOVA). Results: A total of 21 patients were included. Overall QOL was reduced post-discharge (mean score 70.4 (±23.6) vs. 54.6 (±21.0), d=1.628, p=0.0412), however, there was no difference between QOL scores pre-operatively and after 6 months. There was a significant difference after 6 months for physical (mean score 98.4 (±9.6) vs. 85.2 (±14.6), d=1.068, p=0.0017) and role (mean score 92.1 (±17.2) vs. 63.9 (±28.7), d=1.1919, p=0.0005) function-related questions. Reduced appetite, diet restriction and pain were worse following discharge but improved significantly after six months. Conclusions: The results from this study suggest that whilst certain symptoms and functional impairment is common following PD, overall QOL returns to pre-operative levels for most patients.