Progress toward a universal biomedical data translator. Issue 8 (6th June 2022)

• Record Type: Journal Article
• Authors: Fecho, Karamarie; Thessen, Anne E.; Baranzini, Sergio E.; Bizon, Chris; Hadlock, Jennifer J.; Huang, Sui; Roper, Ryan T.; Southall, Noel; Ta, Casey; Watkins, Paul B.; Williams, Mark D.; Xu, Hao; Byrd, William; Dančík, Vlado; Duby, Marc P.; Dumontier, Michel; Glusman, Gustavo; Harris, Nomi L.; Hinderer, Eugene W.; Hyde, Greg; Johs, Adam; Su, Andrew I.; Qin, Guangrong; Zhu, Qian
• Other Names: Dougherty Jennifer investigator.; Huang Conrad investigator.; Magis Andrew investigator.; Smith Brett investigator.; Celebi Remzi investigator.; Chen Zhehuan investigator.; Azevedo Ricardo De Miranda investigator.; Emonet Vincent investigator.; Lee Jay investigator.; Weng Chunhua investigator.; Yilmaz Arif investigator.; Kim Keum Joo investigator.; Santos Eugene investigator.; Tonstad Lucas investigator.; Veenhuis Luke investigator.; Yakaboski Chase investigator.; Acevedo Liliana investigator.; Carrell Steven investigator.; Deutsch Eric investigator.; Glen Amy investigator.; Hoffman Andrew investigator.; Koslicki David investigator.; Kvarfordt Lindsey investigator.; Liu Zheng investigator.; Liu Shaopeng investigator.; Ma Chunyu investigator.; Mendoza Luis investigator.; Muluka Arun Teja investigator.; Womack Finn investigator.; Wood Erica investigator.; Roach Jared investigator.; Goel Prateek investigator.; Weber Rosina investigator.; Williams Andrew investigator.; Gormley Joseph investigator.; Zisk Tom investigator.; Hanspers Kristina investigator.; Hoatlin Maureen investigator.; Pico Alexander investigator.; Riutta Anders investigator.; Callaghan Jackson investigator.; Xu Colleen investigator.; Ahalt Stanley C. investigator.; Balhoff Jim investigator.; Edwards Stephen investigator.; Haaland Perry investigator.; Knowles Michael investigator.; Krishnamurthy Ashok investigator.; Mandal Meisha investigator.; Peden David B. investigator.; Pfaff Emily investigator.; Schurman Shepherd investigator.; Shrivastava Shalki investigator.; Yi Hong investigator.; Reilly Jason investigator.; Kanwar Richa investigator.; Cox Steven investigator.; Vaidya Gaurav investigator.; Wang Max investigator.; Alkanaq Ahmed investigator.; Costanzo Maria investigator.; Koesterer Ryan investigator.; Flannick Jason investigator.; Burtt Noel investigator.; Kluge Alexandria investigator.; Rubin Irit investigator.; Strasser Michael " Michi" investigator.; Chung Lawrence investigator.; Kang Jimin investigator.; Mantilla Michelle investigator.; Muller Sandrine investigator.; Persaud Bria investigator.; Wei Qi investigator.; Baumgartner Andrew investigator.; Dai Cheng investigator.; Duvvuri Venkata investigator.; Mauldin Denise investigator.; Shmulevich Ilya investigator.; Brandon Namdi investigator.; Greyber Alon investigator.; Kebede Yaphet investigator.; Korn Daniel investigator.; Mesbah Abrar investigator.; Owen Phil investigator.; Sakaguchi Rayn investigator.; Seitanakis Sarah investigator.; Tropsha Alexander investigator.; Viola Adam investigator.; Hubal Robert investigator.; Mersmann Marian investigator.; Morton Kenny investigator.; Yao Yao investigator.; Lin Jason investigator.; Avila Ricardo investigator.; Wu Chunlei investigator.; Cano Marco Alvarado investigator.; Gardner Vicki investigator.; Issabekova Tursynay investigator.; McMurry Julie investigator.; Schaper Kevin investigator.; Baumgartner William investigator.; Cohen Kevin investigator.; Gatica Edgar investigator.; Hunter Lawrence investigator.; Price Guthrie investigator.; He Kaiwen investigator.; Henrickson Jeff investigator.; Mamidi Tarun investigator.; Might Matthew investigator.; Osborne John investigator.; Patton Michael investigator.; Rosenblatt Greg investigator.; Tran‐Nguyen Thi investigator.; Crouse Andrew investigator.; Belhu Basazin investigator.; Conlin Tom investigator.; Huellas‐Bruskiewicz Kenneth investigator.; Rudavsky‐Brody Nathaniel investigator.; Shrestha Manil investigator.; Stillwell Lisa investigator.; von Grotthuss Marcin investigator.; Wang Patrick investigator.; Xin Jiwen Kevin investigator.; Zhou Xinghua investigator.; Champion James investigator.; Scott Erik investigator.; Sharma Priya investigator.; Sinha Meghamala investigator.; Raj Shruti investigator.; Mease Philip investigator.; Peene R. Carter investigator.; McClelland Jason investigator.; Schmitt Charles P. investigator.; Leigh Margaret investigator.; Corkill Dan investigator.; Zhou Eric investigator.; Alden John investigator.; Massung Jeffrey investigator.; Brandes Mac Kenzie investigator.; Amin Nada investigator.; Chen Mei‐Jan investigator.; Crowder Camerron investigator.; Crumbley Mary E. investigator.; Fehrmann Nathaniel investigator.; Foksinska Aleksandra M. investigator.; Jenkins Lindsay investigator.; He Kaiwen investigator.; Huls Forest B. investigator.; Jarrell Matthew investigator.; Pollard Elizabeth investigator.; Rucka Sienna investigator.; Southern Nicholas investigator.; Tinglin Jillian investigator.; Whitlock Jordan investigator.; Zheng Marissa investigator.;
• Is Part Of: Clinical and translational science. Volume 15:Issue 8(2022)
• Page Start: 1838
• Page End: 1847
• Publication Date: 2022-06-06
• Subjects: Medicine, Experimental -- Periodicals; Medical innovations -- Periodicals; 616.027
• DOI: 10.1111/cts.13301
• Languages: English
• ISSNs: 1752-8054

Abstract

Abstract: Clinical, biomedical, and translational science has reached an inflection point in the breadth and diversity of available data and the potential impact of such data to improve human health and well‐being. However, the data are often siloed, disorganized, and not broadly accessible due to discipline‐specific differences in terminology and representation. To address these challenges, the Biomedical Data Translator Consortium has developed and tested a pilot knowledge graph‐based "Translator" system capable of integrating existing biomedical data sets and "translating" those data into insights intended to augment human reasoning and accelerate translational science. Having demonstrated feasibility of the Translator system, the Translator program has since moved into development, and the Translator Consortium has made significant progress in the research, design, and implementation of an operational system. Herein, we describe the current system's architecture, performance, and quality of results. We apply Translator to several real‐world use cases developed in collaboration with subject‐matter experts. Finally, we discuss the scientific and technical features of Translator and compare those features to other state‐of‐the‐art, biomedical graph‐based question‐answering systems.