Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction. (15th February 2017)

• Record Type: Journal Article
• Authors: Wookey, Alice F.; Chollangi, Tejasvy; Yong, Hannah E. J.; Kalionis, Bill; Brennecke, Shaun P.; Murthi, Padma; Georgiou, Harry M.
• Other Names: Wing Deborah A. Academic Editor.
• Is Part Of: Journal of pregnancy. Volume 2017(2017)
• Publication Date: 2017-02-15
• Subjects: Pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; Pregnancy; Pregnancy Complications; Pregnancy; Pregnancy -- Complications; Electronic journals; Periodicals; Periodicals; 618.2
• DOI: 10.1155/2017/5120267
• Languages: English
• ISSNs: 2090-2727

Abstract

Abstract : Vitamin D-binding protein is a multifunctional serum protein with multiple actions related to normal health. Vitamin D-binding protein transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory and actin-clearing properties. We investigated whether vitamin D-binding protein expression is altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived from 17 healthy control subjects and 18 gestation-matched subjects with fetal growth restriction (FGR). FGR subjects were further subdivided as idiopathic (n = 9 ) and nonidiopathic (n = 9 ). Vitamin D-binding protein and 25(OH) vitamin D were measured by ELISA and normalized to protein concentration. The results showed significantly reduced levels of placental vitamin D-binding protein (control versus FGR, p < 0.05, Student's t -test) that were strongly associated with idiopathic fetal growth restriction (p < 0.01, Kruskal-Wallis), whereas levels of vitamin D-binding protein were not associated with placental 25(OH) vitamin D stores (p = 0.295, Pearson's correlation). As such, vitamin D-binding protein may be a factor in unexplained placental dysfunction associated with idiopathic fetal growth restriction and may potentially serve as a biomarker of this disease.