Inflammatory Markers Are Positively Associated with Serum trans-Fatty Acids in an Adult American Population. (11th July 2017)

• Record Type: Journal Article
• Authors: Mazidi, Mohsen; Gao, Hong-kai; Kengne, Andre Pascal
• Other Names: Hylemon Phillip B. Academic Editor.
• Is Part Of: Journal of nutrition and metabolism. Volume 2017(2017)
• Publication Date: 2017-07-11
• Subjects: Nutrition -- Periodicals; Metabolism -- Periodicals; Diet in disease -- Periodicals; Metabolic Diseases; Metabolism; Nutrition Disorders; Nutritional Sciences; Diet in disease; Metabolism; Nutrition; Electronic journals; Periodicals; Periodicals; 363.8
• DOI: 10.1155/2017/3848201
• Languages: English
• ISSNs: 2090-0724

Abstract

Abstract : Background and Aim . The relationship between serum trans -fatty acids (TFAs) and systemic inflammation markers is unclear. We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans. Methods . The 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) participants with measured data on hs-CRP and fibrinogen were included. TFAs were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization. Analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters, accounting for the survey design. Results . Of the 5446 eligible participants, 46.8% (n = 2550 ) were men. The mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p = 0.085 ). After adjustment for age and sex, mean serum TFAs rose with the increasing quarters of hs-CRP and fibrinogen (both p < 0.001 ). In linear regression models adjusted for age, sex, race, education, marital status, body mass index, and smoking, serum TFAs were an independent predictor of plasma hs-CRP and fibrinogen levels. Conclusion . A high level of TFAs appears to be a contributor to an unfavourable inflammatory profile. Because serum TFAs concentrations are affected by dietary TFA intake, these data suggest a possible contribution of TFAs intake modulation in the prevention of inflammation-related chronic diseases.