CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI. (28th September 2008)

• Record Type: Journal Article
• Authors: Collot-Teixeira, Sophie; Barbatis, Calypso; Bultelle, Florence; Koutouzis, Michael; Pasterkamp, Gerard; Fraser, Paul; Kyriakides, Zenon S.; Poston, Robin N.; Ristagno, Angelique; McGregor, Lilian; Boulanger, Chantal M.; Leseche, Guy; McGregor, John L.
• Other Names: Boutjdir Mohamed Academic Editor.
• Is Part Of: Journal of biomedicine and biotechnology. Volume 2008(2008)
• Publication Date: 2008-09-28
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Medicine; Biology; Biotechnology; Médecine; Biologie; Biotechnologie; Biology; Biotechnology; Medicine; Biotechnology; Biomedicine; Electronic journals; Periodical; Periodicals; Electronic journals; 610
• DOI: 10.1155/2008/813236
• Languages: English
• ISSNs: 1110-7243

Abstract

Abstract : OxLDL uptake and cholesterol efflux inhibition in macrophages play a key role in atherosclerotic plaque formation, rupture, and thrombotic ischemia. This study investigates genes implicated in OxLDL uptake (CD36, SRA), cholesterol efflux inhibition (adipophilin, ADFP), and inflammatory recruitments of leukocytes (IL-8) in plaque lesion areas (PLAs) compared to nonplaque lesion areas NPLAs) in human carotid endarterectomy specimens. Gene and protein expressions were assayed using quantitative PCR and quantitative immunohistochemistry. Pearson tests were used to investigate potential correlation between (a) different gene expressions and (b) gene expression and patient's plasma constituents. CD36, SRA, ADFP, and IL-8 were shown to be significantly more expressed in PLA compared to NPLA. In PLA, a significant correlation was observed between CD36, SRA, ADFP, and IL-8 mRNA levels. Moreover, CD36 expression level was significantly inversely correlated to plasma marker ApoAI. The above investigated genes/proteins may play a key role in the maturation of atherosclerotic lesions.