Magnetic Fluid Hyperthermia of Rodent Tumors Using Manganese Perovskite Nanoparticles. (14th August 2014)

• Record Type: Journal Article
• Authors: Bubnovskaya, Larissa; Belous, Anatolij; Solopan, Sergej; Kovelskaya, Antonina; Bovkun, Lyudmila; Podoltsev, Alexander; Kondtratenko, Igor; Osinsky, Sergej
• Other Names: Grasset Fabien Academic Editor.
• Is Part Of: Journal of nanoparticles. Volume 2014(2014)
• Publication Date: 2014-08-14
• Subjects: Nanoparticles -- Periodicals; 620.5
• DOI: 10.1155/2014/278761
• Languages: English
• ISSNs: 2314-484X

Abstract

Abstract : Purpose . To test the antitumor activity of magnetic fluid (MF) on the basis of substituted lanthanum-strontium manganite nanoparticles combined with alternating magnetic field (AMF) in experiments with transplanted tumors. Materials and Methods . MF with a size of nanoparticles of 30–40 nm in aqueous agarose solution was investigated. The ability of MF to heat tumor under AMF (300 kHz, 7.7 kA/m) was tested in vivo with rodent tumors (Guerin carcinoma, Walker-256 carcinosarcoma, and Lewis lung carcinoma (3LL)). Results . Single administration of MF into the tumor at a dose of 150 mg/kg (rats) or 200 mg/kg (mice) followed by AMF within 20–30 min (treatment was repeated 3-4-fold) has resulted in the complete regression of tumor in the 35% of rats and 57% of mice. Administration of MF alone or action of AMF alone has not resulted in tumor growth inhibition. The chemomodifying effect of nanohyperthermia was determined, in particular for cisplatinum: thermal enhancement ratio was 2.0. It was also observed that nanohyperthermia has resulted in the absence of 3LL metastases in 43% of mice. Conclusions . MF on the basis of lanthanum-strontium manganite may be considered as an effective inductor of tumor local hyperthermia.