The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. (25th October 2015)
- Record Type:
- Journal Article
- Title:
- The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. (25th October 2015)
- Main Title:
- The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States
- Authors:
- Cates, Jordan E.
Westreich, Daniel
Edmonds, Andrew
Wright, Rodney L.
Minkoff, Howard
Colie, Christine
Greenblatt, Ruth M.
Cejtin, Helen E.
Karim, Roksana
Haddad, Lisa B.
Kempf, Mirjam-Colette
Golub, Elizabeth T.
Adimora, Adaora A. - Other Names:
- Perez-Lopez Faustino R. Academic Editor.
- Abstract:
- Abstract : Background . To evaluate the effects of HIV viral load, measured cross-sectionally and cumulatively, on the risk of miscarriage or stillbirth (pregnancy loss) among HIV-infected women enrolled in the Women's Interagency HIV Study between 1994 and 2013. Methods . We assessed three exposures: most recent viral load measure before the pregnancy ended, log10 copy-years viremia from initiation of antiretroviral therapy (ART) to conception, and log10 copy-years viremia in the two years before conception. Results . The risk of pregnancy loss for those with log10 viral load >4.00 before pregnancy ended was 1.59 (95% confidence interval (CI): 0.99, 2.56) times as high as the risk for women whose log10 viral load was ≤1.60. There was not a meaningful impact of log10 copy-years viremia since ART or log10 copy-years viremia in the two years before conception on pregnancy loss (adjusted risk ratios (aRRs): 0.80 (95% CI: 0.69, 0.92) and 1.00 (95% CI: 0.90, 1.11), resp.). Conclusions . Cumulative viral load burden does not appear to be an informative measure for pregnancy loss risk, but the extent of HIV replication during pregnancy, as represented by plasma HIV RNA viral load, predicted loss versus live birth in this ethnically diverse cohort of HIV-infected US women.
- Is Part Of:
- Infectious diseases in obstetrics and gynecology. Volume 2015(2015)
- Journal:
- Infectious diseases in obstetrics and gynecology
- Issue:
- Volume 2015(2015)
- Issue Display:
- Volume 2015, Issue 2015 (2015)
- Year:
- 2015
- Volume:
- 2015
- Issue:
- 2015
- Issue Sort Value:
- 2015-2015-2015-0000
- Page Start:
- Page End:
- Publication Date:
- 2015-10-25
- Subjects:
- Generative organs, Female -- Infections -- Periodicals
Communicable diseases in pregnancy -- Periodicals
618.142005 - Journal URLs:
- https://www.hindawi.com/journals/idog/ ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1155/2015/362357 ↗
- Languages:
- English
- ISSNs:
- 1064-7449
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4478.729100
British Library HMNTS - ELD Digital store - Ingest File:
- 23055.xml