Maternal Obesity and Rectovaginal Group B Streptococcus Colonization at Term. (2nd August 2015)

• Record Type: Journal Article
• Authors: Kleweis, Shelby M.; Cahill, Alison G.; Odibo, Anthony O.; Tuuli, Methodius G.
• Other Names: Mardh Per Anders Academic Editor.
• Is Part Of: Infectious diseases in obstetrics and gynecology. Volume 2015(2015)
• Publication Date: 2015-08-02
• Subjects: Generative organs, Female -- Infections -- Periodicals; Communicable diseases in pregnancy -- Periodicals; 618.142005
• DOI: 10.1155/2015/586767
• Languages: English
• ISSNs: 1064-7449

Abstract

Abstract : Objective . To test the hypothesis that maternal obesity is an independent risk factor for rectovaginal group B streptococcus (GBS) colonization at term. Study Design . Retrospective cohort study of consecutive women with singleton term pregnancies admitted in labor at Barnes-Jewish Hospital (2004–2008). Maternal BMI ≥ 30 Kg/m 2 (obese) or <30 Kg/m 2 (nonobese) defined the two comparison groups. The outcome of interest was GBS colonization from a positive culture. Baseline characteristics were compared using Student's t -test and Chi-squared or Fisher's exact test. The association between obesity and GBS colonization was assessed using univariable and multivariable analyses. Results . Of the 10, 564 women eligible, 7, 711 met inclusion criteria. The prevalence of GBS colonization in the entire cohort was relatively high (25.8%). Obese gravidas were significantly more likely to be colonized by GBS when compared with nonobese gravidas (28.4% versus 22.2%, P < 0.001 ). Obese gravidas were still 35% more likely than nonobese women to test positive for GBS after adjusting for race, parity, smoking, and diabetes (adjusted OR 1.35 [95% CI 1.21–1.50]). Conclusion . Maternal obesity is a significant risk factor for GBS colonization at term. Further research is needed to evaluate the impact of this finding on risk-based management strategies.