A robust [11C]acetate synthesis on a TRACERLab FX C pro module. (October 2022)

• Record Type: Journal Article
• Authors: Wenz, Jan; Arndt, Felix; Samnick, Samuel
• Is Part Of: Applied radiation and isotopes. Volume 188(2022)
• Publication Date: 2022-10
• Subjects: [11C]acetate -- Carboxylation -- TRACERLab FX C Pro -- Positron emission tomography; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2022.110356
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: Carbon-11 labelled acetate ([ 11 C]acetate) is a radiotracer of importance in clinical practice as well as in preclinical research. The TRACERLab FX C Pro Synthesizer can be used this sensitive carboxylation reaction. Starting from 11 GBq [ 11 C]CO2, we were able to isolate about 3 GBq [ 11 C]acetate after only 20 min reaction time (yield 56 ± 7%, n = 10). Highlights: - Handling of sensitive substances for radiolabeling. - Disposable products for gmp compliant radiopharmaceutical production. - Fully automated synthesis modules flexible for research, preclinic and patient care.