Chemical constituents from the fruits of Illicium simonsii and their antiviral activity and neuroprotective effect. (October 2022)

• Record Type: Journal Article
• Authors: Su, Guo-Zhu; Li, Mi; Wang, Xiao-Jing; Wang, Ru-Bing; Ma, Shuang-Gang; Zhang, Dan; Wang, Xiao-Liang; Li, Li; Liu, Yun-Bao; Qu, Jing; Li, Yu-Huan; Li, Yong; Yu, Shi-Shan
• Is Part Of: Phytochemistry. Volume 202(2022)
• Publication Date: 2022-10
• Subjects: Illicium simonsii -- Illiciaceae -- Diterpenoid -- Sesquiterpene -- Lignan; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2022.113323
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: One undescribed diterpenoid illisimonone A, four undescribed sesquiterpenes named (±)-simonones A, simonterpenoids A and B, and two undescribed lignans, illisimonins A and B, along with five known compounds were isolated from the fruits of Illicium simonsii . Their structures were elucidated by extensive spectroscopic data. The absolute configuration of illisimonone A was determined by single-crystal X-ray diffraction analysis. Illisimonone A showed potential antiviral activity against the Coxsackie B3 virus, with an IC50 value of 3.70 μM. Illisimonin B and henrylactone A showed potential neuroprotective effects against oxygen-glucose deprivation induced cell injury in SK-N-SH cells, with survival rates of 57.6%, 58.0%, respectively. Graphical abstract: Seven undescribed compounds, together with five known compounds were isolated from Illicium simonsii Maxim . Their antiviral and neuroprotective activities were evaluated. Image 1 Highlights: Seven undescribed compounds were isolated from the fruits of Illicium simonsii. The absolute configuration of undescribed compounds were determined by single-crystal X-ray diffraction analysis, ECD calculation, and a modified Mosher's method.