MiR-590–5p: A double-edged sword in the oncogenesis process. (2022)

• Record Type: Journal Article
• Authors: Barwal, Tushar Singh; Singh, Neha; Sharma, Uttam; Bazala, Sonali; Rani, Medha; Behera, Alisha; Kumawat, Ram Kumar; Kumar, Pawan; Uttam, Vivek; Khandelwal, Akanksha; Barwal, Jyoti; Jain, Manju; Jain, Aklank
• Is Part Of: Cancer treatment and research communications. Number 32(2022)
• Publication Date: 2022
• Subjects: MicroRNA -- miR-590-5p -- Cancer -- Biomarker -- Therapeutic target
• DOI: 10.1016/j.ctarc.2022.100593
• Languages: English
• ISSNs: 2468-2942

Abstract

Highlights: miR-590–5p acts as a tumor-suppressor in breast cancer, head and neck cancer, non-small cell lung cancer, and osteosarcoma. miR-590–5p acts as a oncogene in cervical cancer, esophageal cancer, liver cancer, oral cancer, pancreatic cancer, vulvar squamous cell carcinoma, cervical cancer, and bladder cancer. miR-590–5p also acting as dual role in colorectal cancer and gastric cancer. Abstract: Accumulating evidence suggests the critical role of miR-590–5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590–5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590–5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590–5p to resolve this apparent paradox. We have also described the involvement of miR-590–5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590–5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers. Graphical abstract: Image, graphical abstract