Bio-inspired hemocompatible surface modifications for biomedical applications. (October 2022)

• Record Type: Journal Article
• Authors: Douglass, Megan; Garren, Mark; Devine, Ryan; Mondal, Arnab; Handa, Hitesh
• Is Part Of: Progress in materials science. Volume 130(2022)
• Publication Date: 2022-10
• Subjects: Biomaterials -- Medical devices -- Biomimetic -- Hemocompatible; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2022.100997
• Languages: English
• ISSNs: 0079-6425

Abstract

Highlights: A numerical model has been proposed to investigate the performance of STEGB-DPCM. Effect of solar radiation, convective heat transfer and PCM thickness is developed. The behavior of STEGB-PCM is evaluated from electrical and thermal properties. A comparison between STEGB with PCM and without PCM is performed. Abstract: When blood first encounters the artificial surface of a medical device, a complex series of biochemical reactions is triggered, potentially resulting in clinical complications such as embolism/occlusion, inflammation, or device failure. Preventing thrombus formation on the surface of blood-contacting devices is crucial for maintaining device functionality and patient safety. As the number of patients reliant on blood-contacting devices continues to grow, minimizing the risk associated with these devices is vital towards lowering healthcare-associated morbidity and mortality. The current standard clinical practice primarily requires the systemic administration of anticoagulants such as heparin, which can result in serious complications such as post-operative bleeding and heparin-induced thrombocytopenia (HIT). Due to these complications, the administration of antithrombotic agents remains one of the leading causes of clinical drug-related deaths. To reduce the side effects spurred by systemic anticoagulation, researchers have been inspired by the hemocompatibility exhibited by natural phenomena, and thus have begun developing medical-grade surfaces which aim to exhibit total hemocompatibility via biomimicry. This review paper aims to address different bio-inspired surface modifications that increase hemocompatibility, discuss the limitations of each method, and explore the future direction for hemocompatible surface research.