Engulf and digest – TRPM7 as key regulator of macrophage phagosome maturation. (September 2022)

• Record Type: Journal Article
• Authors: Hoeger, Birgit; Zierler, Susanna
• Is Part Of: Cell calcium. Volume 106(2022)
• Publication Date: 2022-09
• Subjects: Macrophages -- Efferocytosis -- Phagosome maturation -- Calcium signaling -- Ion channel -- TRPM7; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2022.102636
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: Commentary on Schappe M.S. et al., Efferocytosis requires periphagosomal Ca 2+ -signaling and TRPM7-mediated electrical activity, Nature Communications, 2022, 13. Abstract: Localized intracellular calcium fluxes are indispensable for immunologically directed Fc receptor-mediated cellular phagocytosis. A similar dependency on calcium signals has been speculated to occur in efferocytosis, the clearance of non-opsonized apoptotic cell bodies by macrophages. In a recent study published in Nature Communications, Schappe et al . describe the TRPM7 ion channel as mediator of peri‑phagosomal calcium currents, ensuring maturation of the acidifying phagosome. The authors identified a fundamental calcium signaling module provided by TRPM7, which is necessary for clearance of apoptotic cells. This finding updates our current molecular understanding of calcium dynamics, tissue maintenance and immunological clean-up. Graphical abstract: Image, graphical abstract