Stereoselective [2+2]-Cycloadditions of chiral allenic ketones and alkenes: Applications towards the synthesis of benzocyclobutenes and endiandric acids. (10th September 2022)

• Record Type: Journal Article
• Authors: Guo, Renyu; Witherspoon, Brittany P.; Brown, M. Kevin
• Is Part Of: Tetrahedron. Volume 122(2022)
• Publication Date: 2022-09-10
• Subjects: Cycloaddition -- Enantioselective -- Lewis-acid -- Allenes -- Cyclobutane; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2022.132932
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Cyclobutanes are important motifs that have found utility in many contexts. Prior work has demonstrated an enantioselective isomerization/stereoselective [2 + 2] as a means to access bicyclo [4.2.0]octanes. Herein, the utility of this method is demonstrated towards the synthesis of benzocyclobutenes and a key intermediate towards the endiandric acids. Graphical abstract: To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Image 1