Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China. (13th April 2017)

• Record Type: Journal Article
• Authors: Zhao, Yanyan; Song, Chunhua; Ma, Xiaokun; Ma, Xiaojun; Wang, Qingzhu; Ji, Hongfei; Guo, Feng; Qin, Guijun
• Other Names: Tura Andrea Academic Editor.
• Is Part Of: International journal of endocrinology. Volume 2017(2017)
• Publication Date: 2017-04-13
• Subjects: Endocrinology -- Periodicals; Endocrinology; Endocrinology -- Periodicals; Endocrine System Diseases -- Periodicals; Periodicals; 616.4
• DOI: 10.1155/2017/9707284
• Languages: English
• ISSNs: 1687-8337

Abstract

Abstract : Background . Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods . This was a cross-sectional survey in central urban China (n = 1234 patients with T2DM and n = 8615 non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index ( S ) scores. Results . After adjustment for age, gender, BMI, and WHR, a uniparental FHD (O R = 2.84, 95% CI: 2.36–3.42, P < 0.001 ), a paternal history of FHD (O R = 2.53, 95% CI: 1.91–3.35, P < 0.001 ), a maternal history of FHD (O R = 3.27, 95% CI: 2.67–4.02, P < 0.001 ), a biparental history of FHD (O R = 5.26, 95% CI: 2.98–9.31, P < 0.001 ), and a FHD, irrespective of the parent (O R = 3.59, 95% CI: 3.08–4.17, P < 0.001 ), were associated with T2DM onset. There were significant interactions between FHD and consuming <15 g/d of potatoes (S = 1.54, 95% CI: 1.12–2.12), <8 g/d of poultry (S = 1.51, 95% CI: 1.04–2.17), <85 g/d of fresh fruits (S = 2.17, 95% CI: 1.63–2.88), and no freshly squeezed juice (S = 2.25, 95% CI: 1.46–3.49). Conclusions . Risk of T2DM was synergistically affected by FHD and dietary habits. Nutrition educational intervention may decrease the prevalence of T2DM in the Chinese with FHD.