Innately Adaptive or Truly Autoimmune: Is There Something Unique About Systemic Juvenile Idiopathic Arthritis?. Issue 2 (2nd January 2020)

• Record Type: Journal Article
• Authors: Kessel, Christoph; Hedrich, Christian M.; Foell, Dirk
• Is Part Of: Arthritis & rheumatology. Volume 72:Issue 2(2020)
• Page Start: 210
• Page End: 219
• Publication Date: 2020-01-02
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.41107
• Languages: English
• ISSNs: 2326-5191

Abstract

Abstract : Systemic juvenile idiopathic arthritis (JIA) is a form of arthritis in childhood that is initially dominated by innate immunity–driven systemic inflammation and is thus considered a polygenic autoinflammatory disease. However, systemic JIA can progress toward an adaptive immunity–driven afebrile arthritis. Based on this observation of biphasic disease progression, a "window of opportunity" for optimal, individualized and target‐directed treatment has been proposed. This hypothesis requires testing, and in this review we summarize current evidence regarding molecular factors that may contribute to the progression from an initially predominantly autoinflammatory disease phenotype to autoimmune arthritis. We consider the involvement of innately adaptive γδ T cells and natural killer T cells that express γδ or αβ T cell receptors but cannot be classified as either purely innate or adaptive cells, versus classic B and T lymphocytes in this continuum. Finally, we discuss our understanding of how and why some primarily autoinflammatory conditions can progress toward autoimmune‐mediated disorders over the disease course while others do not and how this knowledge may be used to offer individualized treatment.