An updated review of the association of host genetic factors with susceptibility and resistance to COVID‐19. Issue 1 (15th June 2020)

• Record Type: Journal Article
• Authors: Mohammadpour, Somayeh; Torshizi Esfahani, Amir; Halaji, Mehrdad; Lak, Mina; Ranjbar, Reza
• Is Part Of: Journal of cellular physiology. Volume 236:Issue 1(2021)
• Page Start: 49
• Page End: 54
• Publication Date: 2020-06-15
• Subjects: COVID‐19 -- genetics -- resistance -- SARS‐CoV‐2 -- susceptibility; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.29868
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in human populations sparked a global pandemic of the coronavirus disease 2019 (COVID‐19). According to preliminary data, about 14% of cases are considered severe and 5% of cases result in critical illness and, reported case fatality rates vary from 1% to more than 7%. However, the symptoms of the disease and the clinical outcome are very different in infected people. In view of these differences, it is clearly apparent that to gain insight into the biology of the SARS‐CoV‐2, it is important to study not just the infectious particle in itself but also to investigate the virus‐host cell interactions that occur during infection. This review seeks to consider the various aspects of genetic factors in determining the susceptibility and host resistance to SARS‐CoV‐2 throughout the recently published literature. Abstract : This review seeks to consider the various aspects of genetic factors in determining the susceptibility and host resistance to severe acute respiratory syndrome coronavirus 2 throughout the recently published literature.