An Efficient Ugi‐Azide Four‐Component Approach for the Preparation of Novel 1‐(1H‐tetrazol‐5‐yl)‐10‐chloro‐1, 2, 3, 4‐tetrahydropyrazino[1, 2‐a] Indoles. (4th March 2019)
- Record Type:
- Journal Article
- Title:
- An Efficient Ugi‐Azide Four‐Component Approach for the Preparation of Novel 1‐(1H‐tetrazol‐5‐yl)‐10‐chloro‐1, 2, 3, 4‐tetrahydropyrazino[1, 2‐a] Indoles. (4th March 2019)
- Main Title:
- An Efficient Ugi‐Azide Four‐Component Approach for the Preparation of Novel 1‐(1H‐tetrazol‐5‐yl)‐10‐chloro‐1, 2, 3, 4‐tetrahydropyrazino[1, 2‐a] Indoles
- Authors:
- Salahi, Saleh
Ghandi, Mehdi
Abbasi, Alireza - Abstract:
- Abstract : The synthesis of novel 1‐(1 H ‐tetrazol‐5‐yl)‐10‐chloro‐1, 2, 3, 4‐tetrahydropyrazino[1, 2‐ a ] indole derivatives starting from the initially prepared 1‐(2‐bromoethyl)‐3‐chloro‐1 H ‐indole‐2‐carbaldehyde is described. A variety of likely biologically relevant pyrazino[1, 2‐ a ] indole‐based 1, 5‐disubstituted tetrazoles was obtained in moderate to high yields via an Ugi‐azide reaction. These reactions presumably proceed by the imine formation, intramolecular cyclization to iminium ion, and nucleophilic addition tandem reactions, respectively. Abstract :
- Is Part Of:
- Journal of heterocyclic chemistry. Volume 56:Number 4(2019)
- Journal:
- Journal of heterocyclic chemistry
- Issue:
- Volume 56:Number 4(2019)
- Issue Display:
- Volume 56, Issue 4 (2019)
- Year:
- 2019
- Volume:
- 56
- Issue:
- 4
- Issue Sort Value:
- 2019-0056-0004-0000
- Page Start:
- 1296
- Page End:
- 1305
- Publication Date:
- 2019-03-04
- Subjects:
- Heterocyclic compounds -- Periodicals
547.59 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/jhet.3499 ↗
- Languages:
- English
- ISSNs:
- 0022-152X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4998.200000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 23042.xml