In vivo antiaging effects of alkaline water supplementation. (1st January 2020)

• Record Type: Journal Article
• Authors: Logozzi, Mariantonia; Mizzoni, Davide; Di Raimo, Rossella; Andreotti, Mauro; Macchia, Daniele; Spada, Massimo; Fais, Stefano
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 35:Number 1(2020)
• Page Start: 657
• Page End: 664
• Publication Date: 2020-01-01
• Subjects: Alkaline water supplementation -- antiaging -- telomerase -- telomeres length -- antioxidant effect; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2020.1733547
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: Telomeres length and telomerase activity are currently considered aging molecular stigmata. Water is a major requirement for our body and water should be alkaline. Recent reports have shown that aging is related to a reduced water intake. We wanted to investigate the effect of the daily intake of alkaline water on the molecular hallmark of aging and the anti-oxidant response. We watered a mouse model of aging with or without alkaline supplementation. After 10 months, we obtained the blood, the bone marrow and the ovaries from both groups. In the blood, we measured the levels of ROS, SOD-1, GSH, and the telomerase activity and analysed the bone marrow and the ovaries for the telomeres length. We found reduced ROS levels and increased SOD-1, GSH, telomerase activity and telomeres length in alkaline supplemented mice. We show here that watering by using alkaline water supplementation highly improves aging at the molecular level.