Chitosan-based systems aimed at local application for vaginal infections. (1st June 2021)
- Record Type:
- Journal Article
- Title:
- Chitosan-based systems aimed at local application for vaginal infections. (1st June 2021)
- Main Title:
- Chitosan-based systems aimed at local application for vaginal infections
- Authors:
- Araujo, Victor Hugo Sousa
de Souza, Maurício Palmeira Chaves
Carvalho, Gabriela Corrêa
Duarte, Jonatas Lobato
Chorilli, Marlus - Abstract:
- Graphical abstract: Highlights: Mucoadhesive systems for vaginal administration. Mucoadhesive systems composed of chitosan. Mucoadhesive systems composed of chitosan intended for the treatment of infectious vaginal diseases. Abstract: Vaginal administration is a promising route for the local treatment of infectious vaginal diseases since it can bypass the first-pass metabolism, drug interactions, and adverse effects. However, the commercial products currently available for topical vulvovaginal treatment have low acceptability and do not adequately explore this route. Mucoadhesive systems can optimize the efficacy of drugs administered by this route to increase the retention time of the drug in the vaginal environment. Several polymers are used to develop mucoadhesive systems, among them chitosan, a natural polymer that is highly biocompatible and technologically versatile. Thus, the present review aimed to analyze the studies that used chitosan to develop mucoadhesive systems for the treatment of local vaginal infections. These studies demonstrated that chitosan as a component of mucoadhesive drug delivery systems (DDS) is a promising device for the treatment of vaginal infectious diseases, due to the intrinsic antimicrobial activity of this biopolymer and because it does not interfere with the effectiveness of the drugs used for the treatment.
- Is Part Of:
- Carbohydrate polymers. Volume 261(2021)
- Journal:
- Carbohydrate polymers
- Issue:
- Volume 261(2021)
- Issue Display:
- Volume 261, Issue 2021 (2021)
- Year:
- 2021
- Volume:
- 261
- Issue:
- 2021
- Issue Sort Value:
- 2021-0261-2021-0000
- Page Start:
- Page End:
- Publication Date:
- 2021-06-01
- Subjects:
- Chitosan -- Bacterial vaginosis -- Vulvovaginal candidiasis -- Trichomoniasis -- Vaginitis
Polysaccharides -- Periodicals
Polysaccharides -- Periodicals
Polysaccharides -- Périodiques
Electronic journals
547.78 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01448617 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.carbpol.2021.117919 ↗
- Languages:
- English
- ISSNs:
- 0144-8617
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3050.990480
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 23024.xml