Germline mutation and aberrant transcripts of WWOX in a syndrome with multiple primary tumors. Issue 1 (17th June 2019)

• Record Type: Journal Article
• Authors: Xu, Ao; Wang, Wei; Nie, Jinfu; Lui, Vivian WY; Hong, Bo; Lin, Wenchu
• Is Part Of: Journal of pathology. Volume 249:Issue 1(2019)
• Page Start: 19
• Page End: 25
• Publication Date: 2019-06-17
• Subjects: WWOX -- aberrant transcripts -- germline mutation -- multiple primary tumors -- colon and ovarian cancers; Pathology -- Periodicals; 616.07
• DOI: 10.1002/path.5288
• Languages: English
• ISSNs: 0022-3417

Abstract

Abstract: Multiple primary tumors are defined by the presence of two or more independent primary tumors in the same or different organs of an individual patient. However, the underlying genetic cause for the development of multiple primary tumors is largely unknown. In the study, we report a rare case with four synchronous distinct histological cancer types in a 26 years old Chinese female. In the patient, whole‐exome sequencing identified a homozygous germline insertion mutation in WWOX which encodes the DNA repair‐related enzyme, WW domain containing oxidoreductase. The mutation was found in a heterozygous state in her parents and brother without any cancer phenotype thus far. Surprisingly, we found multiple novel aberrant WWOX transcripts in the patient's normal colon tissue. The patient's colon metastasis from clear cell adenocarcinoma of the ovary showed a nonhypermutated profile enriched for C‐T transition, and harbored somatic pathogenic mutations of HRAS, BRCA2, SMAD4, CHEK2, and AKT1 genes. To our knowledge, this is the first study reporting WWOX gene aberrations in a young patient with the early occurrence of multiple primary tumors. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.