Favipiravir and Zanamivir Cleared Infection with Influenza B in a Severely Immunocompromised Child. (3rd March 2020)

• Record Type: Journal Article
• Authors: Lumby, Casper K; Zhao, Lei; Oporto, Macarena; Best, Tim; Tutill, Helena; Shah, Divya; Veys, Paul; Williams, Rachel; Worth, Austen; Illingworth, Christopher J R; Breuer, Judy
• Is Part Of: Clinical infectious diseases. Volume 71:Number 7(2020)
• Page Start: e191
• Page End: e194
• Publication Date: 2020-03-03
• Subjects: influenza -- favipiravir -- zanamivir -- genome sequencing; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa023
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral samples illuminated the within-host dynamics of infection, demonstrating the effectiveness of favipiravir in this case.