A new ligand for copper-catalyzed amination of aryl halides to primary(hetero)aryl amines. Issue 13 (26th March 2020)

• Record Type: Journal Article
• Authors: Jiang, Shang; Dong, Xinrui; Qiu, Yatao; Chen, Dong; Wu, Xiaoxing; Jiang, Sheng
• Is Part Of: Tetrahedron letters. Volume 61:Issue 13(2020)
• Publication Date: 2020-03-26
• Subjects: Copper-catalyzed -- Amination -- New ligand -- Cyclopentane-1, 1-dicarboxamide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.151683
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient method to prepare primary (hetero)aryl amines was developed. Ligand 2 was found to be a novel efficient ligand for copper-catalyzed amination. This method used cheap aqueous ammonia as the amino source. This method was proceeded under mild conditions with broad substrate scope. Abstract: N, N ′-Bis(3, 5-dimethoxyphenyl)cyclopentane-1, 1-dicarboxamide was found as a new ligand for copper-catalyzed amination of aryl iodides, bromides and chlorides to afford various primary (hetero)aryl amines. These reactions proceeded efficiently under mild conditions when inexpensive aqueous ammonia (28% NH3 in H2 O) was used as the amino source.