MicroRNAs in hematopoietic stem cell aging. (July 2020)

• Record Type: Journal Article
• Authors: Luinenburg, Daniëlle Gaby; de Haan, Gerald
• Is Part Of: Mechanisms of ageing and development. Volume 189(2020)
• Publication Date: 2020-07
• Subjects: Hematopoietic stem cell -- Aging -- microRNA; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2020.111281
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Hematopoietic stem cells show a distinct functional decline upon aging. MicroRNAs form an intricate network that regulates hematopoietic stem cells. MicroRNAs that enhance quiescence, self-renewal and differentiation are targets for hematopoietic stem cell rejuvenation. The role of microRNAs in age-associated processes and diseases inform understanding phenotypes observed upon aging. Abstract: The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.