Aging, obese-insulin resistance, and bone remodeling. (October 2020)

• Record Type: Journal Article
• Authors: Imerb, Napatsorn; Thonusin, Chanisa; Chattipakorn, Nipon; Chattipakorn, Siriporn C.
• Is Part Of: Mechanisms of ageing and development. Volume 191(2020)
• Publication Date: 2020-10
• Subjects: μCT micro CT -- β2AR β2 adrenergic receptor -- 2-AG 2-arachidonoylglyceral -- Adipo.Ar adipocyte area -- AEA Arachidonoyl ethanolamide -- ALP alkaline phosphatase -- APC Adipogenic progenitor cell -- AR androgen receptors -- B.Ar bone area -- B.Pm bone perimeter -- BALP bone specific alkaline phosphatase -- BFR Bone formation rate -- BFR/BS Bone formation per bone surface -- BMD Bone mineral density -- BSP bone sialoprotein -- BV bone volume -- BV/TV Bone volume per total volume -- C:R carbonate to phosphate ratio -- CBFβ core-binding factor beta -- Cbfa1 core binding factor alpha1 -- CEBPα CCAAT enhancer binding protein alpha -- CEBPβ CCAAT enhancer binding protein beta -- CEBPγ CCAAT enhancer binding protein gramma -- CID 1st First cycle indentation distance -- CID creep indentation distance -- CLA conjugated linoleic acids -- Conn.D Connectivity density -- Ct. Th cortical thickness -- Ct.Ar Cortical area -- Ct.BA Cortical bone area -- Ct.Po cortical porosity -- Ct.th cortica l thickness -- CTX-I carboxy terminal crosslinked telopeptides of type I collagen -- CTX carboxy-terminal collagen crosslinks -- CV/TV Cartilage volume per tissue volume -- DAGL Diacylglycerol lipases -- Dio2 type II iodothyronine deiodinase -- DKK-1 Dickkopf-related protein 1 -- DPD Deoxypyridinoline -- DPP4 dipeptidyl peptidase 4 -- ECR enzymatic crosslink ratio -- Efailure energy to failure -- Emod elasticity module -- ERα estrogen receptor alpha -- Es. Pm endosteal perimeter. F.max maximum force -- FABP4 fatty acid binding protein 4 -- FBG fibrinogen -- FOXC2 Forkhead box protein C2 -- FV/TV Fat volume per tissue volume -- GLUT4 glucose transporter 4 -- GSH reduced glutathione -- GSK GlaxoSmithKline -- HF or HFD high-fat diet -- IDI Indentation distance increase -- IGF-1 Insulin-like growth factor 1 -- KO knock out -- Kyn kynurenine -- Lc layered co-culture -- Lep leptin -- LPS lipopolysaccharide -- M-CSF macrophage colony-stimulating factor -- Ma.Ar marrow area -- MAGL monacylglycerol lipases -- MAPKs mitogen-activated kinases -- MAR Mineral appositional rate -- Mc monoculture -- MDA Malondialdehyde -- Me.Ar medullary area -- MFR/BS Mineral surface per bone surface -- Min.Peri Mineralizing perimeter -- MMP matrix metalloproteinases -- MMR matrix maturity ratio mineral-to-matrix ratio -- MOI moment of inertia -- MSCs mesenchymal stromal cells -- N.Adipo number of adipocytes -- N.Oc/B.Pm number of osteoclast per bone perimeter -- N.oc/BS number of osteoclast per bone surface -- ND normal diet -- NE-xLR non-enzymatic crosslink ratio -- NE norepinephrine -- NECR Non-enzymatic crosslink ratio -- NF-κB nuclear factor κB -- NPY Neuropeptide Y -- NTX-I Amino-terminal crosslinked telopeptide of collagen -- OcOCN osteocalcin -- OP Osteopontin -- OPC Osteogenic progenitor cell -- OPG osteoprotegerin -- Os.f Osteoclast surface per bone surface -- Osteoid srf/ pm Osteoid surface per bone perimeter -- P1NP procollagen type I N-terminal propeptide -- PAI-1 plasminogen activator inhibitor 1 -- PGC1α Peroxisome-proliferator-activated receptor γ coactivator 1-alpha -- PLG plasminogen -- PPARγ peroxisome proliferator activated receptor grammar -- Prdm1 PR domain zinc finger protein 1 -- PreAd Preadipocyte -- Ps. Pm periosteal perimeter -- PTH parathyroid hormone -- PTM Proximal tibia metaphysis -- PYD pyridinoline -- RID reference-point indentation -- ROS reactive oxygen species -- Runx2 Runt-related transcription factor 2 -- S-CTx Serum CTx -- Sca-1 stem cell antigen-1 -- SMI structural model index -- T.Ar total area -- TAZ Transcriptional coactivator with a PDZ binding domain -- Tb. BV/TV trabecular bone volume per tissue volume -- Tb. N trabecular number -- Tb. Sp trabecular separation -- Tb. Th trabecular thickness -- Tb.D Trabecular density -- Tc Transwell co-culture -- TDI total distance increase -- TGF-β transforming growth factor beta -- TID total indentation distance -- TMD Tissue mineral density -- TRAF6 tumor necrosis factor receptor-associated with factor 6 -- TRAP tratrate-resistant acid phosphatase -- TRAP5b tartrate-resistance acid phosphatase 5b -- Tt.Ar total a rea -- TV total volume -- UCP1 uncoupling protein 1 -- V vehicle -- W.Th wall thickness -- WT wild type -- YAP Yes-associated protein -- β3AR beta-3 adrenergic receptor -- μCT micro computed tomography; Aging -- Obesity -- Insulin resistance -- Bone remodeling; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2020.111335
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Hallmarks of skeletal aging and a decline in bone remodeling regulators cause age-related bone loss. Obese-insulin resistance exacerbated deleterious effects on bone remodeling in aged condition. Synergistic effects of the obese and aged conditions lead to severe acceleration of bone loss. Reduction in BAT, Thy-1 and DOCK7 are causes of skeletal tissue deterioration in elderly-obese. The interventions also improve age- and obesity-related bone remodeling deterioration. Abstract: Aging, obesity, and insulin resistance are known to cause the impairment of bone regulation, resulting in an imbalance in bone homeostasis and pathological bone. The natural deterioration associated with the aging process, including increased adipogenicity, menopause, andropause and alteration of mesenchymal stem cell fate have been shown to be potential causes of decreased bone density, resulting in osteoporosis, in which is a major risk factor of bone fracture in elderly people. Furthermore, functional limitations of the aging musculoskeletal system cause physical inactivity and increased adipogenicity. Therefore obesity in aged population has been dramatically observed. Several evidence demonstrated that obesity in aged individual leads to the acceleration and aggravation of unfavorable effects to general health, particularly the deterioration of bone health, including reduction in bone formation, increased bone resorption, greater adipose tissue accumulation, impaired bone architecture, and bone fragility. Therefore, the present review aimed to summarize and discuss the effects of aging, obesity, and aging with obesity on bone remodeling. The possible mechanistic insights of bone homeostasis and the interventions for the improvement of bone quality in aged and obese individuals have been included and discussed.