Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. (July 2020)

• Record Type: Journal Article
• Authors: Chakraborty, Apala; Banerjee, Soumyabrata; Mukherjee, Biswajit; Poddar, Mrinal Kanti
• Is Part Of: Mechanisms of ageing and development. Volume 189(2020)
• Publication Date: 2020-07
• Subjects: ACTH adrenocorticotropic hormone -- ANOVA analysis of variance -- BDNF brain-derived neurotrophic factor -- BSA bovine serum albumin -- CA1 cornu ammonis 1 (Hippocampal subfield) -- CC Cerebral cortex -- CNS Central nervous system -- CR calorie restriction -- CRH corticotrophin releasing hormone -- EDTA Ethylene diamine tetra acetic acid -- EOS Ethanolamine-O-sulphate -- FeCl3 Ferric chloride -- GABA gamma-aminobutyric acid -- GABA-T GABA-transaminase -- GAD Glutamate decarboxylase -- GDH Glutamate dehydrogenase -- GS Glutamine synthetase -- HCl Hydrochloric acid -- HI Hippocampus -- HPA Hypothalamic-pituitary-adrenocortical -- HY Hypothalamus -- H2SO4 Sulfuric acid -- IAEC Institutional animal ethical committee -- ICMR Indian council of medical research -- IGF Insulin-like growth factor -- MBTH 3-methyl-2-benzo-thiazoline-2-hydrazone -- mRNA messenger RNA -- mTOR mammalian target of rapamycin -- NaNO2 Sodium nitrite -- PALPO Pyridoxal-5′-phosphate -- PM Pons-medulla -- PVN paraventricular nucleus -- REM rapid eye movement -- SIRT1 Sirtuin1 -- TCA Trichloroacetic acid; Aging -- Brain regional GABA -- Calorie restriction -- Corticosterone -- Cognitive function; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2020.111248
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Aging deregulates cognitive function, brain regional GABA and corticosterone. Calorie restricted (CR) diet improves these aging-induced deregulations. Longer period of CR diet supplementation produces greater effect. CR diet consumption is harmful to young rats as observed in their parameters studied. Abstract: Aging is known to affect adversely the corticosterone status and the brain function including cognition. Calorie restricted (CR) diet has been found to improve brain aging. The objective of the present investigation is to study the effect of short-term CR diet without any food deprivation on aging-induced impairment of cognitive function in relation to the corticosterone status and the brain regional GABA system. The result showed that aging-induced deregulation of the brain regional GABA system, increase in plasma and adrenal corticosterone levels and cognitive impairment were attenuated with short-term CR diet supplementation for consecutive 1 and 2 months to the aged (18 and 24 months) rats. But in young rats (4 months) consumption of the same CR diet under similar conditions reversibly affected those above-mentioned parameters. These results, thus suggest that (a) aging down-regulates brain regional GABA system with an up-regulation of corticosterone status and impairment of cognitive function, (b) CR diet consumption improves this aging-induced deregulation of brain regional GABA system, corticosterone status, and cognitive function, (c) these attenuating effects of CR diet are greater with a longer period of consumption but (d) CR diet consumption is harmful to young rats as observed in those parameters.