Peripheral insulin-like growth factor 1 in bipolar disorder. (April 2017)

• Record Type: Journal Article
• Authors: da Silva, Emily G.; Pfaffenseller, Bianca; Walz, Julio; Stertz, Laura; Fries, Gabriel; Rosa, Adriane R.; Magalhães, Pedro V.
• Is Part Of: Psychiatry research. Volume 250(2017)
• Page Start: 30
• Page End: 34
• Publication Date: 2017-04
• Subjects: Bipolar disorder -- IGF-1 -- Neurotrophins -- Inflammation; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.01.061
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Bipolar disorder is a recurrent and highly incapacitating illness, related to inflammation and changes in the insulin-like growth factor 1 (IGF-1). The objective of this study was to evaluate serum levels of IGF-1 in bipolar disorder patients and its relation to inflammation. We included 31 patients with bipolar disorder and 33 healthy controls. Serum concentrations of IGF-1, growth hormone (GH), insulin and tumor necrosis factor α (TNF-α) were analyzed. The serum levels of IGF-1 seem to be increased in bipolar disorder patients (248.84±104.91 ng/mL) compared to controls (169.18±74.16 ng/mL). Comparing reference values of IGF serum concentrations between groups, we found that 32% of patients had increased IGF-1 serum concentrations while only 3% of subjects are above normal range. We did not find statistically significant differences between groups in the concentration of insulin, GH, and TNF-α. This study suggests an association between IGF-1 in the pathophysiology of bipolar disorder. It is possible that this peripheral increase is related to a central nervous system increased resistance to IGF-1, thus reducing its neuroprotective action. Highlights: We evaluated IGF-1 serum levels in bipolar disorder euthymic patients. There was a significant increase in IGF-1 serum levels in bipolar disorder patients. There is evidence of IGF-1 role in specific brain regions, such as hippocampus, which is also impared in the bipolar disorder.