A one-pot synthesis of PEGylated plasmonic WO3−x@Eugenol nanoflowers with NIR-controllable antioxidant activities for synergetically combating bacterial biofilm infection. Issue 15 (21st June 2022)

• Record Type: Journal Article
• Authors: Xie, Xianghong; Zhang, Mingyu; Lei, Yulu; Li, Ying; Sun, Jing; Sattorov, Nosirjon; Makhmudov, Kamoljon Burkhonovich; Zhu, Ming-Qiang; Wang, Jianlong
• Is Part Of: Inorganic chemistry frontiers. Volume 9:Issue 15(2022)
• Page Start: 3808
• Page End: 3819
• Publication Date: 2022-06-21
• Subjects: Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d2qi00571a
• Languages: English
• ISSNs: 2052-1553

Abstract

Abstract : Schematic diagram of dual treatment of bacterial infection. Abstract : Serious wound infection by the colonization and development of drug-resistant bacteria has attracted widespread attention of the society with the urge for searching advanced antibacterial methods. The NIR-triggered antimicrobial photothermal therapy (PTT) using nanomaterials as energy donors has the advantage of a wide antibacterial spectrum, but it is still restricted by its low efficacy. Herein, we propose a PTT-driven bioactive molecule controllable release system (PEG-WO3− x @EL NFs), which is developed with tungsten trioxide nanoflowers as a carrier. Benefiting from the photothermal effect of PEG-WO3− x NFs and the inherent bactericidal properties of EL (eugenol), the nanoplatform achieves an extremely strong bactericidal ability against Salmonella and methicillin-resistant Staphylococcus aureus . Notably, the nanoplatform presents outstanding capacity to prevent biofilm formation. More importantly, the nanoplatform displays significant antioxidant capacity to realize the rapid recovery of infected wounds. As a consequence, our study has the potential to provide an urgent breakthrough for wound biofilm therapy.