Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes. (13th December 2018)

• Record Type: Journal Article
• Authors: Yang, Feng; Zheng, Zhi; Xue, Xuchao; Zheng, Luming; Qin, Jianmin; Li, Haijia; Zhou, Yuhong; Fang, Guoen
• Is Part Of: Future oncology. Volume 15:Number 3(2019)
• Page Start: 281
• Page End: 295
• Publication Date: 2018-12-13
• Subjects: cancer stem cells -- CD44 -- gastric cancer -- immunoliposomes -- USP22; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2018-0295
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: USP22, a member of ubiquitin-specific proteases (USPs), is a well-defined protein that promotes poor prognosis, invasion and metastasis, and also participates in the maintenance of cancer stem cells. USP22 siRNA-loaded nanoliposomes conjugated with CD44 antibodies (USP22-NLs-CD44) were constructed to enhance the therapeutic effect of USP22 siRNA against gastric cancer stem cells.Materials & methods: The targeting and therapeutic efficacies of USP22-NLs-CD44 against gastric cancer stem cells were evaluated.Results & conclusion: USP22-NLs-CD44 was demonstrated to be able to effectively deliver USP22 siRNA to CD44 + gastric cancer stem cells, achieving superior therapeutic effects against CD44 + gastric cancer stem cells than nontargeted nanoliposomes. USP22-NLs-CD44 may provide a novel approach to eradicate gastric cancer stem cells in the near future.