Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites. (15th November 2018)

• Record Type: Journal Article
• Authors: Palmieri, Valentina; Bugli, Francesca; Cacaci, Margherita; Perini, Giordano; Maio, Flavio De; Delogu, Giovanni; Torelli, Riccardo; Conti, Claudio; Sanguinetti, Maurizio; Spirito, Marco De; Zanoni, Robertino; Papi, Massimiliano
• Is Part Of: Nanomedicine. Volume 13:Number 22(2018)
• Page Start: 2867
• Page End: 2879
• Publication Date: 2018-11-15
• Subjects: coating -- curcumin -- graphene -- immunology/infectious diseases -- nanocomposites -- PEGylation -- preventive medicine -- targeted therapy; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2018-0183
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections.Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO–CU–PEG) were drop-casted on surfaces and antifungal efficacy was assessed.Results: We demonstrate that GO–CU–PEG coatings can reduce fungal adhesion, proliferation and biofilm formation. Furthermore, in an aqueous environment, surfaces release curcumin–PEG nanocomposites that have a minimum inhibitory concentration of 9.25 μg/ml against C. albicans .Conclusion: Prevention of early cell adhesion and creation of a proximal environment unfavorable for growth make these GO-supported biomaterials attractive for innovative medical device manufacturing.