Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis. (6th December 2018)

• Record Type: Journal Article
• Authors: Som, Avik; Raliya, Ramesh; Paranandi, Krishna; High, Rachel A; Reed, Nathan; Beeman, Scott C; Brandenburg, Matthew; Sudlow, Gail; Prior, Julie L; Akers, Walter; Mah-Som, Annelise Y; Habimana-Griffin, Lemoyne; Garbow, Joel; Ippolito, Joseph E; Pagel, Mark D; Biswas, Pratim; Achilefu, Samuel
• Is Part Of: Nanomedicine. Volume 14:Number 2(2019)
• Page Start: 169
• Page End: 182
• Publication Date: 2018-12-06
• Subjects: magnetite -- MRI -- nano-CaCO3 -- pH modulation -- theranostic; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2018-0302
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: CaCO3 nanoparticles (nano-CaCO3 ) can neutralize the acidic pHe of solid tumors, but the lack of intrinsic imaging signal precludes noninvasive monitoring of pH-perturbation in tumor microenvironment. We aim to develop a theranostic version of nano-CaCO3 to noninvasively monitor pH modulation and subsequent tumor response.Materials & methods: We synthesized ferromagnetic core coated with CaCO3 (magnetite CaCO3 ). Magnetic resonance imaging (MRI) was used to determine the biodistribution and pH modulation using murine fibrosarcoma and breast cancer models.Results: Magnetite CaCO3 -MRI imaging showed that nano-CaCO3 rapidly raised tumor pHe, followed by excessive tumor-associated acid production after its clearance. Continuous nano-CaCO3 infusion could inhibit metastasis.Conclusion: Nano-CaCO3 exposure induces tumor metabolic reprogramming that could account for the failure of previous intermittent pH-modulation strategies to achieve sustainable therapeutic effect.