Zn-doped CuO nanocomposites inhibit tumor growth by NF-κB pathway cross-linked autophagy and apoptosis. (5th November 2018)

• Record Type: Journal Article
• Authors: Xu, Huanli; Yuan, Ru; Liu, Xiaohui; Li, Xiao; Qiao, Gan; Li, Cong; Gedanken, Aharon; Lin, Xiukun
• Is Part Of: Nanomedicine. Volume 14:Number 2(2019)
• Page Start: 131
• Page End: 149
• Publication Date: 2018-11-05
• Subjects: apoptosis -- autophagy -- cancer therapy -- cytotoxicity -- N-acetylcysteine -- nanoparticles -- NF-κB pathways -- reactive oxygen species -- tumor growth -- Zn-doped CuO nanocomposites; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2018-0366
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: To investigate the antitumor effects and action mechanism of Zn-doped CuO nanocomposites (Zn-CuONPs).Materials & methods: Therapeutic effects and mechanisms of Zn-CuONPs were investigated both in vitro and in vivo .Results: Zn-CuONPs could inhibit tumor growth both in vitro and in vivo significantly. Zn-CuONPs treatment resulted in cytotoxicity, reactive oxygen species (ROS) production, DNA damage, apoptosis and autophagy. ROS scavenger N -acetylcysteine attenuated all of the above effects induced by Zn-CuONPs. N -acetylcysteine also restored the effects of Zn-CuONPs on protein expressions related to apoptosis, autophagy and NF-κB pathways. NF-κB pathway inhibitor pyrrolidine dithiocarbamate significantly attenuated Zn-CuONPs induced apoptosis and autophagy.Conclusion: Our data demonstrated that Zn-CuONPs could inhibit tumor growth both in vitro and in vivo by ROS-dependent apoptosis and autophagy cross-linked by NF-κB pathways. Graphical abstract: