Intravascular cell therapy in stroke: predicting the future trends. (18th December 2018)

• Record Type: Journal Article
• Authors: Cui, Lili; Moisan, Anaïck; Jolkkonen, Jukka
• Is Part Of: Regenerative medicine. Volume 14:Number 1(2019)
• Page Start: 63
• Page End: 68
• Publication Date: 2018-12-18
• Subjects: cell therapy -- efficacy -- future trends -- intravascular delivery -- mechanisms -- safety -- stroke -- update; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme-2018-0037
• Languages: English
• ISSNs: 1746-0751

Abstract

This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational success and accelerate clinical development of safe and efficient cell products.