Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement. (26th June 2014)

• Record Type: Journal Article
• Authors: Kidher, Emaddin; Patel, Vanash M.; Nihoyannopoulos, Petros; Anderson, Jon R.; Chukwuemeka, Andrew; Francis, Darrel P.; Ashrafian, Hutan; Athanasiou, Thanos
• Other Names: Deleu Dirk Academic Editor.
• Is Part Of: Neurology research international. Volume 2014(2014)
• Publication Date: 2014-06-26
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8005
• DOI: 10.1155/2014/970793
• Languages: English
• ISSNs: 2090-1852

Abstract

Abstract : Background . Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods . Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results . Fifty-six patients (71 ± 8.4 years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group (n = 21 ) than in PWV-norm group (n = 35 ; median 1.8 ± 1.2 versus 1.2 ± 0.7, resp., P = 0.003 ). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion . Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.