The ever –present need for biopsy to diagnose coeliac disease safely. (July 2022)

• Record Type: Journal Article
• Authors: Rai, Anuradha; Mittal, Santosh; Taneja, Kanchan; Mahajan, Nidhi
• Is Part Of: Tropical doctor. Volume 52:Number 3(2022)
• Page Start: 411
• Page End: 412
• Publication Date: 2022-07
• Subjects: Anti-tissue transglutaminase antibody -- giardiasis -- coeliac disease; Tropical medicine -- Periodicals; Medical care -- Developing countries -- Periodicals; Developing Countries -- Periodicals; Tropical Medicine -- Periodicals; Tropische geneeskunde; 616.9883
• DOI: 10.1177/00494755221079042
• Languages: English
• ISSNs: 0049-4755

Abstract

Coeliac disease (CD) is an autoimmune enteropathy which occurs in genetically predisposed individuals on exposure to gluten. The recommended diagnostic approach includes serological screening by Anti-tissue Transglutaminase antibody (anti-tTG) followed by a small intestinal biopsy. As high anti-tTG antibody is expected to be significantly associated with MARSH III histopathological changes in the small intestine, it has now become the basis for a biopsy-free approach to diagnose CD. However, we report cases of giardiasis mimicking CD both clinically and serologically; differentiation demands small intestinal biopsy.