Curcumin-Impregnated Drug Delivery Systems May Show Promise in the Treatment of Diseases Secondary to Traumatic Brain Injury: Systematic Review. Issue 2 (June 2022)

• Record Type: Journal Article
• Authors: Yilmaz, İbrahim; Karaarslan, Numan; Somay, Hakan; Ozbek, Hanefi; Ates, Ozkan
• Is Part Of: Journal of pharmacology and pharmacotherapeutics. Volume 13:Issue 2(2022)
• Page Start: 190
• Page End: 196
• Publication Date: 2022-06
• Subjects: Curcumin -- Nanodrug -- Oxidative stress -- Traumatic brain injury; 615.1
• DOI: 10.1177/0976500X221112479
• Languages: English
• ISSNs: 0976-500X

Abstract

Objective: To find out whether curcumin can be effective in the treatment of traumatic brain injury (TBI). Methods: A comprehensive and systematic literature search in the PubMed electronic database was performed. Descriptive statistics were used to evaluate the data obtained. The results were presented as frequency and percentage (%) or amount. Results: Two clinical trials investigated curcumin for the treatment of TBI. One study tested curcumin in living mammalian subjects using an amyloLipid nanovesicle. In three studies, curcumin was investigated together with the drug delivery system for the treatment of TBI. Conclusion: Drug delivery systems prepared with nanomaterials may have a potential therapeutic effect in treating TBI by increasing neuroprotection because they can penetrate the central nervous system more rapidly.