Six‐Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing. Issue 45 (26th July 2022) - Wang, Lulu
Abstract: Invited for the cover of this issue are Dang Cheng, Fener Chen and co‐workers at Fudan University. The image depicts six‐step continuous‐flow synthesis of diclofenac sodium from commercially available aniline and chloroacetic acid in a desktop microchemical plant. Read the full text of the article at 10.1002/chem.202201420 . Abstract : " The sensitive amide hydrolysis of N ‐(2, 6‐dichlorophenyl)‐2‐hydroxy‐ N ‐phenylacetamide… was perfectly suppressed in this developed flow chemistry, thereby avoiding the generation of… waste… inevitable in the current batch process ." This and more about the story behind the front cover can be found in the article at 10.1002/chem.202201420 ).