Emerging Approaches for Enabling RNAi Therapeutics. Issue 16 (30th June 2022)

• Record Type: Journal Article
• Authors: Mallick, Argha M.; Tripathi, Archana; Mishra, Sukumar; Mukherjee, Asmita; Dutta, Chiranjit; Chatterjee, Ananya; Sinha Roy, Rituparna
• Is Part Of: Chemistry, an Asian journal. Volume 17:Issue 16(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-30
• Subjects: siRNA -- gene silencing -- drug delivery -- endosomal escape, lipids -- polymers -- peptides.; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.202200451
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: RNA interference (RNAi) is a primitive evolutionary mechanism developed to escape incorporation of foreign genetic material. siRNA has been instrumental in achieving the therapeutic potential of RNAi by theoretically silencing any gene of interest in a reversible and sequence‐specific manner. Extrinsically administered siRNA generally needs a delivery vehicle to span across different physiological barriers and load into the RISC complex in the cytoplasm in its functional form to show its efficacy. This review discusses the designing principles and examples of different classes of delivery vehicles that have proved to be efficient in RNAi therapeutics. We also briefly discuss the role of RNAi therapeutics in genetic and rare diseases, epigenetic modifications, immunomodulation and combination modality to inch closer in creating a personalized therapy for metastatic cancer. At the end, we present, strategies and look into the opportunities to develop efficient delivery vehicles for RNAi which can be translated into clinics. Abstract : Technologies for enabling RNAi therapeutics discusses the advancements made in the field of diverse types of delivery vehicles, with a special emphasis on peptide‐based delivery vehicles. Delivery is one of the key hurdles for enabling RNAi therapeutics. Here we have also discussed the application of RNAi therapeutics mainly in cancer treatment.