The mystery of mitochondrial plasticity: TMBIM5 integrates metabolic state and proteostasis. (1st August 2022)

• Record Type: Journal Article
• Authors: Ren, Mindong; Schlame, Michael
• Is Part Of: EMBO journal. Volume 41:Number 16(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-01
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2022111834
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : How cellular cues alter the mitochondrial proteome and impact the composition of mitochondrial proteins remains poorly understood. In this issue of The EMBO Journal, Patron et al (2022) identify TMBIM5 as an important link between calcium homeostasis, proton motive force, and mitochondrial proteolysis, by which the organelle can modify its protein composition. The results may be crucial for our understanding of the plasticity of mitochondria. Abstract : Recent work identifies TMBIM5 as inner mitochondrial membrane Ca 2+ /H + exchanger, linking hyperpolarisation regulation to proteome control and energy metabolism.