Treatment of gingivitis is associated with reduction of systemic inflammation and improvement of oral health‐related quality of life: A randomized clinical trial. (17th July 2022)

• Record Type: Journal Article
• Authors: Perić, Marina; Marhl, Urska; Gennai, Stefano; Marruganti, Crystal; Graziani, Filippo
• Is Part Of: Journal of clinical periodontology. Volume 49:Number 9(2022)
• Page Start: 899
• Page End: 910
• Publication Date: 2022-07-17
• Subjects: acute inflammation -- C‐reactive protein -- gingivitis -- quality of life; Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.13690
• Languages: English
• ISSNs: 0303-6979

Abstract

Abstract: Aim: To compare the level of inflammatory markers, oral health‐related quality of life (OHRQoL), and gingival parameters 1 month after introduction of electric toothbrush and intensive oral hygiene manoeuvre adaptation (OHI) versus routine habits (no‐OHI) in patients affected by generalized gingivitis. Materials and Methods: One hundred forty subjects with generalized gingivitis were randomized to receive either OHI or no‐OHI. Full‐mouth plaque/bleeding scores (FMPS/FMBS), serum high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐6 (IL‐6), and an oral health impact profile‐14 questionnaire were collected at baseline and at 1‐month follow‐up visit. Results: In the OHI, a significant FMPS and FMBS reduction ( p < .01), a significant intra‐group decrease in hs‐CRP and IL‐6 ( p < .01), and a significant improvement of OHRQoL ( p < .01) were noted at 1‐month follow‐up visit. In the no‐OHI, lower‐magnitude differences were noted only for oral parameters. Resolution of gingivitis varied between OHI and no‐OHI (89% vs. 7%, respectively, p < .01). A logistic multivariate regression suggested that FMBS ≤8% was associated with the odds ratio of 13, having both CRP and IL‐6 below the selected threshold for healthy young adults ( p = .04). Conclusions: Gingivitis resolution determined important reductions of gingival inflammation and plaque levels, as well as systemic inflammatory markers and an improvement of quality of life (NCT03848351).