Chemical Factory‐Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer. Issue 23 (16th June 2022)

• Record Type: Journal Article
• Authors: Tang, Zhongmin; Wu, Shiman; Zhao, Peiran; Wang, Han; Ni, Dalong; Li, Huiyan; Jiang, Xingwu; Wu, Yelin; Meng, Yun; Yao, Zhenwei; Cai, Weibo; Bu, Wenbo
• Is Part Of: Advanced science. Volume 9:Issue 23(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-06-16
• Subjects: chemical factory -- Fenton -- liver cancer -- metabolism -- zinc peroxide; Science -- Periodicals; 505
• DOI: 10.1002/advs.202201232
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: In the field of nanomedicine, there is a tendency of matching designed nanomaterials with a suitable type of orthotopic cancer model, not just a casual subcutaneous one. Under this condition, knowing the specific features of the chosen cancer model is the priority, then introducing a proper therapy strategy using designed nanomaterials. Here, the Fenton chemistry is combined with zinc peroxide nanoparticles in the treatment of orthotopic liver cancer which has a "chemical factory" including that liver is the main place for iron storage, metabolism, and also the main metabolic sites for the majority of ingested substances, guaranteeing customized and enhanced chemodynamic therapy and normal liver cells protection as well. The good results in vitro and in vivo can set an inspiring example for exploring and utilizing suitable nanomaterials in corresponding cancer models, ensuring well‐fitness of nanomaterials for disease and satisfactory therapeutic effect. Abstract : The chemical factory of orthotopic liver cancer has laid a solid foundation for introducing chemodynamic therapy into orthotopic liver cancer. The orthotopic liver cancer therapy is realized through customized microenvironment/chemical factory‐guaranteed enhanced Fenton/Fenton‐like reactions by using the polyethylene glycol‐modified zinc peroxide (ZnO2 @PEG) nanoparticles.