International Validation of the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score. Issue 4 (21st February 2022)

• Record Type: Journal Article
• Authors: Doets, Alex Y.; Walgaard, Christa; Lingsma, Hester F.; Islam, Badrul; Papri, Nowshin; Yamagishi, Yuko; Kusunoki, Susumu; Dimachkie, Mazen M.; Waheed, Waqar; Kolb, Noah; Gorson, Kenneth C.; Jacobs, Bart C.
• Other Names: Islam Zhahirul investigator.; Mohammad Quazi Deen investigator.; Harbo Thomas investigator.; Sindrup Soren H. investigator.; Chavada Govindsinh investigator.; Davidson Amy investigator.; Willison Hugh J. investigator.; Casasnovas Carlos investigator.; Bateman Kathleen investigator.; Miller James A.L. investigator.; van Doorn Pieter A. investigator.; van den Berg Bianca investigator.; Verboon Christine investigator.; Roodbol Joyce investigator.; Leonhard Sonja E. investigator.; Arends Samuel investigator.; Luijten Linda investigator.; Benedetti Luana investigator.; Kuwabara Satoshi investigator.; den Bergh Peter Van investigator.; Monges Soledad investigator.; Marfia Girolama A. investigator.; Shahrizaila Nortina investigator.; Galassi Giuliana investigator.; Pereon Yann investigator.; Bürmann Jan investigator.; Kuitwaard Krista investigator.; Kleyweg Ruud P. investigator.; Marchesoni Cintia investigator.; Sedano Tous María J. investigator.; Querol Luis investigator.; Wang Yuzhong investigator.; Nobile‐Orazio Eduardo investigator.; Rinaldi Simon investigator.; Schenone Angelo investigator.; Pardo Julio investigator.; Vermeij Frederique H. investigator.; Lehmann Helmar C. investigator.; Granit Volkan investigator.; Cavaletti Guido investigator.; Gutiérrez‐Gutiérrez Gerardo investigator.; Barroso Fabio A. investigator.; Visser Leo H. investigator.; Katzberg Hans D. investigator.; Dardiotis Efthimios investigator.; Attarian Shahram investigator.; van der Kooi Anneke J. investigator.; Eftimov Filip investigator.; Wirtz Paul W. investigator.; Samijn Johnny P.A. investigator.; Gilhuis H. Jacobus investigator.; Hadden Robert D.M. investigator.; Holt James K.L. investigator.; Sheikh Kazim A. investigator.; Karafiath Summer investigator.; Vytopil Michal investigator.; Antonini Giovanni investigator.; Feasby Thomas E. investigator.; Faber Catharina G. investigator.; Kramers J.C.H.M. (Hans) investigator.; Busby Mark investigator.; Roberts Rhys C. investigator.; Silvestri Nicholas J. investigator.; Fazio Raffaella investigator.; van Dijk Gert W. investigator.; Garssen Marcel P.J. investigator.; Verschuuren Jan G.G.M. investigator.; Hughes R.A.C. investigator.; Cornblath D.R. investigator.; Hartung H.P. investigator.; de Koning L.C. investigator.; van Woerkom M. investigator.; Mandarakas M. investigator.; Reisin R.C. investigator.; Reddel S.W. investigator.; Ripellino P. investigator.; Hsieh S.T. investigator.; Addington J.M. investigator.; Ajroud‐Driss S. investigator.; Andersen H. investigator.; Badrising U.A. investigator.; Bella I.R. investigator.; Bertorini T.E. investigator.; Bhavaraju‐Sanka R. investigator.; Bianco M. investigator.; Brand P. investigator.; Brannagan T.H. investigator.; Briani Chiara investigator.; Butterworth S. investigator.; Chao C.C. investigator.; Chen S. investigator.; Claeys K.G. investigator.; Conti M.E. investigator.; Cosgrove J.S. investigator.; Dalakas M.C. investigator.; Derejko M.A. investigator.; de la Coeur C. Dornonville investigator.; Echaniz‐Laguna A. investigator.; Fokke C. investigator.; Fujioka T. investigator.; Fulgenzi E.A. investigator.; García‐Sobrino T. investigator.; Gilchrist J.M. investigator.; Goldstein J.M. investigator.; Goyal N.A. investigator.; Grimbergen Y.A.M. investigator.; Grisanti S. investigator.; Gutmann L. investigator.; Illa I. investigator.; Holbech J.V. investigator.; Htut M. investigator.; Jellema K. investigator.; Pascual I. Jericó investigator.; Jimeno‐Montero M.C. investigator.; Kaida K. investigator.; Khoshnoodi M. investigator.; Kimpinski K. investigator.; Kuwahara M. investigator.; Kiers L. investigator.; Kokubun N. investigator.; Kwan J.Y. investigator.; Ladha S.S. investigator.; Lassen L. Landschoff investigator.; Lawson V. investigator.; Pan E. Lee investigator.; Lunn M.P.T. investigator.; Magot A. investigator.; Manji H. investigator.; Infante C. Márquez investigator.; Martín‐Aguilar L. investigator.; Hernandez E. Martinez investigator.; Mataluni G. investigator.; Mattiazzi M.G. investigator.; McDermott C.J. investigator.; Meekins G.D. investigator.; de la Tassa G. Morís investigator.; Mozzoni J. investigator.; Nascimbene C. investigator.; Nedkova V. investigator.; Nowak R.J. investigator.; Balaguer P. Orizaola investigator.; Osei‐Bonsu M. investigator.; Pascuzzi R.M. investigator.; Prada V. investigator.; Pulley M.T. investigator.; Rojas‐Marcos I. investigator.; Rudnicki S.A. investigator.; Sachs G.M. investigator.; Samukawa M. investigator.; Santoro L. investigator.; Schwindling L. investigator.; Sekiguchi Y. investigator.; Sommer C.L. investigator.; Song Y. investigator.; Stein B. investigator.; Stino A.M. investigator.; Tan C‐Y. investigator.; Tankisi H. investigator.; Twydell P.T. investigator.; van Damme P. investigator.; van der Ree T. investigator.; van Koningsveld R. investigator.; Varrato J.D. investigator.; Zhou L. investigator.; Zivkovic S. investigator.;
• Is Part Of: Annals of neurology. Volume 91:Issue 4(2022)
• Page Start: 521
• Page End: 531
• Publication Date: 2022-02-21
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.26312
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : Objective: This study aimed to validate the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score in the International Guillain–Barré Syndrome Outcome Study cohort, and to improve its performance and region‐specificity. Methods: We examined data from the first 1, 500 included patients, aged ≥6 years and not ventilated prior to study entry. Patients with a clinical variant or mild symptoms were also included. Outcome was mechanical ventilation within the first week from study entry. Model performance was assessed regarding the discriminative ability (area under the receiver operating characteristic curve) and the calibration (observed vs predicted probability of mechanical ventilation), in the full cohort and in Europe/North America and Asia separately. We recalibrated the model to improve its performance and region‐specificity. Results: In the group of 1, 023 eligible patients (Europe/North America n = 842, Asia n = 104, other n = 77), 104 (10%) required mechanical ventilation within the first week from study entry. Area under the curve values were ≥0.80 for all validation subgroups. Mean observed proportions of mechanical ventilation were lower than predicted risks: full cohort 10% versus 21%, Europe/North America 9% versus 21%, and Asia 17% versus 23%. After recalibration, predicted risks for the full cohort and Europe/North America corresponded to observed proportions. Interpretation: This prospective, international cohort study validated the Erasmus Guillain–Barré Syndrome Respiratory Insufficiency Score, and showed that the model can be used in the full spectrum of Guillain–Barré syndrome patients. In addition, a more accurate, region‐specific version of the model was developed for patients from Europe/North America. ANN NEUROL 2022;91:521–531