Bridging stem cell research and medicine: a learning health system. (25th July 2018)

• Record Type: Journal Article
• Authors: Touré, Seydina B; Kleiderman, Erika; Knoppers, Bartha M
• Is Part Of: Regenerative medicine. Volume 13:Number 6(2018)
• Page Start: 741
• Page End: 752
• Publication Date: 2018-07-25
• Subjects: learning health system -- regenerative medicine -- stem cells; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme-2017-0129
• Languages: English
• ISSNs: 1746-0751

Abstract

Stem cells may not systematically obey traditional Phase I–IV clinical translation models. In response, various actors have suggested that stem cell-based medical innovation models could catalyze translation instead. Accordingly, calls were made to adopt more permissive approaches to stem cell translation. Yet, the Phase I–IV paradigm remains the standard within the scientific community. This article seeks to advance the stalemated discussions by proposing an alternative model for consideration. In it, we argue that a stem cell-based learning health system may be able to reconcile these two models. Centered on the acceleration of evidence and knowledge flow, a stem cell-based learning health system could maximize patient retention and data follow-up, thereby promoting inclusive system learning and improvement.