Polymorphism of PARP-1 indicates an increased risk and a worse initial severity of ischemic stroke. (27th September 2018)

• Record Type: Journal Article
• Authors: Meng, Dianhuai; He, Wei; Huang, Peng; Liu, Dinghua; Zhong, Lingling; Yu, Rongbin; Li, Jianan
• Is Part Of: Personalized medicine. Volume 15:Number 5(2018)
• Page Start: 355
• Page End: 360
• Publication Date: 2018-09-27
• Subjects: DNA repair system -- ischemic stroke -- PARP-1 -- polymorphism -- prognosis -- susceptibility; Pharmacogenomics -- Periodicals; Pharmacogenetics -- Periodicals; 615.19
• DOI: 10.2217/pme-2018-0007
• Languages: English
• ISSNs: 1741-0541

Abstract

Aim: Polymorphisms of DNA repair enzyme gene may alter the ability to repair damage and in turn may contribute to ischemic stroke susceptibility and outcome.Methods: We selected 316 ischemic stroke patients and 302 healthy controls. Then we genotyped SNPs of PARP-1 rs3219119, rs2271347 and APE1 rs1130409 in patient and control groups.Results: Polymorphism in PARP-1 rs2271347 was significantly associated with increased ischemic stroke risk (additive model: OR: 1.74; 95% CI: 1.03–2.93; p = 0.037). Patients harboring the PARP-1 rs2271347 GA/AA genotype had a worse initial stroke (additive model: OR: 1.85; 95% CI: 1.10–3.11; p = 0.021).Conclusion: Our study suggests that genetic variant of rs2271347 may contribute to the etiology of ischemic stroke.