Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway. (11th April 2018)

• Record Type: Journal Article
• Authors: Yang, Xue; Xiao, Xiang; Wang, Hailian; Li, Yi; Wang, Li; Li, Guisen; Deng, Shaoping
• Other Names: Oh Ki-Wan Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2018(2018)
• Publication Date: 2018-04-11
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2018/3450141
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : The aim of the study was to investigate the protective effect of Danhong injection (DHI) on diabetic kidney disease and explore the potential mechanisms. Diabetic kidney disease was induced by unilateral nephrectomy, high-fat diet, and streptozotocin. After DHI administration, the renal function deterioration, 24-hour total urine protein excretion, and elevated serum lipid levels were reversed to some extent, and the renal pathological damage was also ameliorated. The KEGG pathway enrichment analysis demonstrated that the PPAR γ signal pathway was significantly upregulated in DH group. And the increased expressions of PPAR γ and UCP-1 were confirmed by immunohistochemistry, whereas the p38MAPK was significantly decreased. These data show that DHI could delay the progress of DKD, and the effect might be achieved in part by activating the PPAR γ signaling pathway.